| Structure-Based Discovery and Optimization of Furo[3,2- c]pyridin-4(5 H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors |
Junhua Li, Cheng Zhang, Hongrui Xu, Chao Wang, Ruibo Dong, Hui Shen, Xiaoxi Zhuang, Xiaoshan Chen, Qiu Li, Jibu Lu, Maofeng Zhang, Xishan Wu, Kerry M Loomes, Yulai Zhou, Yan Zhang, Jinsong Liu, Yong Xu |
2022 Mar; |
Journal of Medicinal Chemistry |
| Human induced-T-to-natural killer cells have potent anti-tumour activities |
Zhiwu Jiang, Le Qin, Yuou Tang, Rui Liao, Jingxuan Shi, Bingjia He, Shanglin Li, Diwei Zheng, Yuanbin Cui, Qiting Wu, Youguo Long, Yao Yao, Zhihui Wei, Qilan Hong, Yi Wu, Yuanbang Mai, Shixue Gou, Xiaoping Li, Robert Weinkove, Sam Norton, Wei Luo, Weineng Feng, Hongsheng Zhou, Qifa Liu, Jiekai Chen, Liangxue Lai, Xinwen Chen, Duanqing Pei , Thomas Graf, Xingguo Liu, Yangqiu Li, Pentao Liu, Zhenfeng Zhang, Peng Li |
2022 Mar; |
Biomarker Research |
| Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites |
Yang Liu, Jizeng Zhou, Ting Lan, Xiaoqing Zhou, Yang Yang, Chuan Li, Quanjun Zhang, Min Chen, Shu Wei, Shuwen Zheng, Lingyin Cheng, Yuling Zheng, Liangxue Lai, Qingjian Zou |
2022 Mar; |
Cell Discovery |
| Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage |
Md Abdul Mazid, Carl Ward, Zhiwei Luo, Chuanyu Liu , Yunpan Li, Yiwei Lai, Liang Wu, Jinxiu Li, Wenqi Jia, Yu Jiang, Hao Liu, Lixin Fu, Yueli Yang, David P Iba？ez, Junjian Lai , Xiaoyu Wei, Juan An, Pengcheng Guo, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Fei Gao, Junwen Wang, Shahriar Zaman, Baoming Qin, Guangming Wu, Patrick H Maxwell, Xun Xu, Longqi Liu, Wenjuan Li, Miguel A Esteban |
2022 Mar; |
Nature |
| Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents |
Guoqiang Yao, Jianchen Yu, Cai Lin, Yujia Zhu, Anna Duan, Mengfeng Li, Jie Yuan, Jiancun Zhang |
2022 Mar; |
European Journal of Medicinal Chemistry |
| Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis |
Meifeng Zheng, Yingying Lin, Wei Wang, Yu Zhao, Xichen Bao |
2022 Feb; |
Wiley Interdisciplinary Review- RNA |
| Mechanistic insights of CRISPR/Cas nucleases for programmable targeting and early-stage diagnosis: A review |
Jean de Dieu Habimana, Rongqi Huang, Bertrand Muhoza, Yvan Ndayambaje Kalisa, Xiaobo Han, Weiyue Deng, Zhiyuan Li |
2022 Jan; |
Biosens & Bioelectronics |
| Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders |
Jibu Lu, Yongjun Huang, Jing Huang, Rui He, Minhao Huang, Xiaoyun Lu, Yong Xu, Fengtao Zhou, Zhang Zhang, Ke Ding |
2022 Jan; |
Journal of Medicinal Chemistry |
| Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation |
Qi Long, Yanshuang Zhou, Hao Wu, Shiwei Du, Mingli Hu, Juntao Qi, Wei Li, Jingyi Guo, Yi Wu, Liang Yang, Ge Xiang, Liang Wang, Shouhua Ye, Jiayuan Wen , Heng Mao, Junwei Wang, Hui Zhao, Wai-Yee Chan, Jinsong Liu, Yonglong Chen , Pilong Li, Xingguo Liu |
2021 Dec; |
NATURE STRUCTURAL & MOLECULAR BIOLOGY |
| Organocatalytic Asymmetric Arylation of p_x001e_Quinone Phosphonates: A Green Access to Biaryl Monophosphorus Ligands |
Guodong Sun, Zhuofei Deng, Zhonghua Luo, Zhongqing Wang,Jiancun Zhang |
2021 Oct; |
Organic Letters |
| Exacerbated AIDS progression by PD-1 blockade during therapeutic vaccination in chronically SIV-infected rhesus macaques after ART treatment interruption |
Chunxiu Wu, Yizi He, Jin Zhao, Kun Luo, Ziyu Wen, Yudi Zhang, Minchao Li, Yilan Cui , Zijian Liu, Congcong Wang, Zirong Han, Guangye Li, Fengling Feng, Pingchao Li, Ling Chen, Caijun Sun |
2021 Nov; |
Journal of Virology |
| HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6 |
Menghui Yin, Meidie Cheng, Chengli Liu, Keli Wu, Wei Xiong, Ji Fang, Yinxiong Li, Biliang Zhang |
2021 Oct; |
iScience |
| Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis |
Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi |
2021 Oct; |
iScience |
| MAP2K6 Remodels Chromatin and Facilitates Reprogramming by Activating Gatad2b-Phosphorylation Dependent Heterochromatin Loosening |
Guangsuo Xing, Zichao Liu, Luyuan Huang, Danyun Zhao, Tao Wang, Hao Yuan, Yi Wu, Linpeng Li, Qi Long, Yanshuang Zhou, Zhihong Hao, Yang Liu, Jianghuan Lu, Shiting Li, Jieying Zhu, Bo Wang, Junwei Wang, Jing Liu, Jiekai Chen, Duanqing Pei, Xingguo Liu, Keshi Chen |
2021 Nov; |
Cell Death & Differentiation |
| Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses |
Ruona Shi , Zhenhuan Feng , Xiaofei Zhang |
2021 Nov; |
Genomics Proteomics & Bioinformatics |
